Shizuku Kanzaki is the son of a recently deceased, world renowned wine critic named Yutaka Kanzaki. In order to take ownership of his father's legacy, an extensive wine collection featuring some of the most rare labels of the last 30 years, he must find 13 wines, known as the "Twelve Apostles" and the heaven sent "Drops of God" that his father described in his will. But despite being an only child, Shizuku is not alone in this unique wine hunt. He has a competitor. Issei Tomine, a renowned young wine critic, was recently adopted into the Kanzaki family and is also vying for this most rare of prizes.

Shizuku has never consumed, nor had any previous knowledge about wines, but with strong senses of taste and smell, honed from years of time spent with his father, Shizuku accepts the challenge, albeit with a little push from a young sommelier in training named Miyabi. In many ways his mentor and his muse, Miyabi teaches Shizuku the basics of wine and allows Shizuku to nurture his given talents as he begins his journey across the globe in search of the 13 bottles his father has selected for him to someday taste.